NCT01198925.

Trial name or title	Assessment of the optimal dosing of piperacillin‐tazobactam in intensive care unit patients: extended vs continuous infusion
Methods	Randomised, open‐label, pharmacokinetic/pharmacodynamic trial
Participants	Estimated enrolment = 30, adults admitted to the intensive care unit
Interventions	Piperacillin‐tazobactam 4 g i.v. loading dose infused over 30 minutes, then 4 x 4‐g i.v. infused over 3 h (extended infusion) vs piperacillin‐tazobactam 4 g i.v. loading dose infused over 30 minutes, then 16 g i.v. infused over 24 h (continuous infusion)
Outcomes	Primary outcome: pharmacokinetics of piperacillin continuous infusion compared with piperacillin extended infusion Secondary outcome: 95% probability of target attainment vs MIC of different organisms
Starting date	September 2010
Contact information	Johan Decruyenaere (johan.decruyenaere@ugent.be)
Notes	Did not report estimated study completion date