| Trial name or title |
The pharmacodynamics of imipenem in critically ill patients with ventilator‐associated pneumonia following administration by 4 h or 0.5 h infusion |
| Methods |
Randomised, open‐label pharmacokinetics/pharmacodynamics trial |
| Participants |
Estimated enrolment = 12, critically ill patients > 20 years old with ventilator‐associated pneumonia with gram‐negative bacilli infections |
| Interventions |
Imipenem 0.5 g i.v. infused over 0.5 h q6h vs imipenem 1 g i.v. infused over 4 h q8h; treatment duration 3 to 5 days |
| Outcomes |
Primary outcome: pharmacokinetic/pharmacodynamic parameters |
| Starting date |
November 2011 |
| Contact information |
Sutep Jaruratanasirikul (jasutep@medicine.psu.ac.th) |
| Notes |
Estimated study completion date December 2012 |
