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. 2022 Mar 15;14(6):1499. doi: 10.3390/cancers14061499

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Live/Dead assay and Senescence assay of Human Neuronal Cells After 3 Day Treatment Shows Low Level of Toxicity. Low values indicate less death or senescent cells. (A) Live/Dead assay conducted on human neuronal cells cultured with drug for 3 days. (B) Senescence assay results of senescence associated beta-galactosidase staining on human neuronal cells cultured with drug for 3 days. Treatments with best reduction of proliferation in NG108-15 or U87 cells are shown out of a 24-sample toxicity screen, with significant values shown. **: q < 0.01, *: q < 0.05 (one-way ANOVA with FDR post hoc analysis n > 3 technical replicates). Increase in percent dead or senescent cells indicative of toxic treatment.

Live/Dead assay and Senescence assay of Human Neuronal Cells After 3 Day Treatment Shows Low Level of Toxicity. Low values indicate less death or senescent cells. (A) Live/Dead assay conducted on human neuronal cells cultured with drug for 3 days. (B) Senescence assay results of senescence associated beta-galactosidase staining on human neuronal cells cultured with drug for 3 days. Treatments with best reduction of proliferation in NG108-15 or U87 cells are shown out of a 24-sample toxicity screen, with significant values shown. **: q < 0.01, *: q < 0.05 (one-way ANOVA with FDR post hoc analysis n > 3 technical replicates). Increase in percent dead or senescent cells indicative of toxic treatment.