TABLE 3.
Results of synergy testing with Streptococcus pneumoniaea
| MIC (μg/ml)
|
Result for drug combination at time (h)b
|
|||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clinafloxacin | Vancomycin | Penicillin | Cefotaxime | Quinupristin-dalfopristin | Clinafloxacin + vancomycin
|
Clinafloxacin + penicillin
|
Clinafloxacin + cefotaxime
|
Clinafloxacin + quinupristin-dalfopristin
|
||||||||
| 6 | 12 | 24 | 6 | 12 | 24 | 6 | 12 | 24 | 6 | 12 | 24 | |||||
| 0.12 | 0.25 | 4 | 2 | 0.5 | Ad | Ad | Ad | Ad | Ad | Sy (0.03/2) | Ad | Ad | Sy (0.03/1) | Ad | Ad | Ad |
| 0.12 | 0.25 | 4 | 2 | 0.5 | Ad | Ad | Ad | Ad | Ad | Sy (0.06/2) | Ad | Sy (0.06/1) | Sy (0.06/1) | Ad | Ad | Ad |
| 0.12 | 0.25 | 4 | 1 | 0.5 | Ad | Ad | Ad | Ad | Ad | Ad | Ad | Ad | Ad | Ad | Ad | Ad |
a
Three strains were tested.
b
Sy, synergistic; Ad, additive. Values in parentheses are MICs, i.e., indicate the lowest concentrations (in micrograms per milliliter) of each compound that yielded a ≥2-log10 decrease in CFU per milliliter compared to the more active single compound.