Figure 2.
CW15337 is preferentially cytotoxic in CLL cells that carry a BIRC3 or NOTCH1 mutation. (A) All of the CLL samples tested had low micromolar LD50 values, with a mean of 1.44 μM for the entire cohort. (B) Comparative analysis of the sensitivity to CW15337 in CLL prognostic subsets revealed that samples derived from patients carrying a BIRC3 or NOTCH1 mutation were particularly sensitive to CW15337; the same samples showed increased in vitro resistance to fludarabine. *** p < 0.001, and * p < 0.05. ns = not significant.