Figure 3.

CW15337 preferentially inhibits the nuclear expression of p52 and RelB NF-κB subunits. (A) Each cell line evaluated showed a distinct pattern of constitutive NF-κB subunit activation in nuclear extracts. (B) Exposure to CW15337 resulted in a concentration-dependent reduction in two non-canonical NF-κB subunits, p52 and RelB. (C) MEC-1 cells treated with increasing concentrations of CW15337 showed a marked inhibition of p100 processing to p52. (D) Constitutive p52 expression in nuclear extracts from primary CLL samples (n = 15) were correlated with in vitro sensitivity to CW15337. **** p < 0.0001, ** p < 0.01 and * p < 0.05. ns = not significant.