Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Mar 15;14(6):1489. doi: 10.3390/cancers14061489

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

CW15337 is synergistic with fludarabine and ABT-199 in the setting of CD40L 3T3 co-culture. Primary CLL cells showed a marked increase in resistance to (A) fludarabine and (B) ABT-199 when co-cultured on CD40L 3T3 cells. (C) In contrast, the sensitivity to CW15337 was not significantly affected by CD40L co-culture. The combination of CW15337 with (D) fludarabine and (E) ABT-199 showed synergistic interactions. (F) The combination of CW15337 and ABT-199 (100:1) was shown to be particularly synergistic under CD40L co-culture conditions, using SynergyFinder software (https://synergyfinder.fimm.fi, accessed on 30 January 2022). BLISS scores ≥ 10 indicate synergy, the average synergy score of CW15337 and ABT-199 was 15.06. **** p < 0.0001, *** p < 0.001.