Table 2.

Distribution of relative ADC histogram parameters and relative mean, minimum and maximum ADC values among the two tumor entities and the DMG-subtypes.

Compared Pairs (n)	rADC (10)	rADC (25)	rADC (75)	rADC (90)	Skewness	Kurtosis	Entropy	rADC (Mean)	rADC (Min)	rADC (Max)
DMG(30)/ midGBM-H3wt (14)	1.23/1.10	1.31/1.23	1.64/1.59	1.83/1.80	1.50/0.85	4.54/1.02	4.27/4.33	1.51/1.43	0.86/0.74	2.92/2.80
p-value	0.083	0.445	0.686	0.780	0.016	0.002	0.737	0.446	0.128	0.633
95%-CI	−0.01–0.26	−013–0.29	−0.18–0.26	−0.21–0.27	0.12–1.17	1.33–5.69	0.46–0.33	−012–0.28	−0.03–0.24	−0.35–0.58
DMG-GBMneg(13)/ midGBM-H3wt (14)	1.33/1.10	1.46/1.23	1.75/1.59	1.94/1.80	1.19/0.85	4.21/1.02	4.39/4.33	1.59/1.44	1.00/0.74	2.66/2.81
p-value	0.012	0.027	0.210	0.298	0.420	0.083	0.838	0.182	<0.001	0.589
95%-CI	0.05–0.39	0.02–0.42	−0.09–0.41	−0.13–0.42	−0.53–1.20	−0.47–6.84	−0.48–0.58	−0.07–0.38	0.14–0.36	−0.69–0.40
DMG-GBMneg(13)/ DMG-GBMpos (17)	1.33/1.15	1.46/1.20	1.75/1.55	1.94/1.74	1.19/1.74	4.21/4.79	4.39 /4.17	1.59/1.46	1.00/0.55	2.66/3.06
p-value	0.036	0.028	0.141	0.178	0.253	0.779	0.403	0.279	0.001	0.090
95%-CI	−0.01–0.37	−0.00–0.51	−0.07–0.46	−0.09–0.49	−1.53–0.41	−4.81–3.64	−0.29–0.72	−0.11–0.37	0.12–0.39	−0.96–0.073

All numbers shown are mean values. rADC: relative ADC value; min: minimum; max: maximum; DMG: diffuse midline glioma, H3 K27M-mutant; midGBM-H3wt: glioblastoma of the midline structures, H3 K27M-wildtype.; DMG-GBMneg: diffuse midline glioma, H3 K27M-mutant without glioblastoma histology; DMG-GBMpos: diffuse midline glioma, H3 K27M-mutant with glioblastoma histology; CI: confidence interval regarding differences of mean values in each compaired pair. Significant values are shown in bold (t-test).