Table 5.
Comparison of different tumor groups in terms of strong enhancement, rim enhancement and necrosis in MRI considering histological features of malignancy (microvascular proliferations, microscopic necrosis).
| Compared Pairs (n) | Strong Enhancement %/% |
Rim Enhancement %/% |
Necrosis in MRI %/% |
|---|---|---|---|
| DMG (39)/midGBM-H3wt (18) | 38%/56% | 44%/67% | 62%/89% |
| p-value | 0.262 | 0.155 | 0.060 |
| DMG-GBMneg (15)/midGBM-H3wt (18) | 7%/56% | 0/67% | 7%/89% |
| p-value | 0.004 | <0.001 | <0.001 |
| DMG-GBMneg (15)/DMG-GBMpos (24) | 7%/58% | ||
| p-value | 0.002 |
DMG: diffuse midline glioma, H3 K27M-mutant; midGBM-H3wt: glioblastoma of the midline structures, H3 K27M-wildtype.; DMG-GBMneg: diffuse midline glioma, H3 K27M-mutant without glioblastoma histology; DMG-GBMpos: diffuse midline glioma, H3 K27M-mutant with glioblastoma histology. Significant p-values are shown in bold.