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. 2022 Mar 20;14(6):1580. doi: 10.3390/cancers14061580

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Antibody-mediated Treg depletion. Anti-CTLA-4 bound to Tregs can engage with FcγRs expressed on innate cells to deplete Tregs. Macrophages and natural killer cells can deplete Tregs through antibody-dependent cellular phagocytosis (ADCP) and antibody-dependent cellular cytotoxicity (ADCC). Depleting intra-tumoral Tregs promotes anti-tumor immune responses by transforming the immunosuppressive nature of the tumor microenvironment into a pro-inflammatory microenvironment. This is enabled by indirectly increasing anti-tumor effector T-cells’ activation, infiltration, and effector functions.