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NAMPT inhibitor was able to repress protein aggregation signals. Although all the inhibitors tested (NAMPT, SIRT1 and HSP70) reduced the aggregation signals in Detroit 562, the NAMPT inhibitor had the most pronounced effect in reducing the protein aggregation. The protein aggregation signal was calculated as the OD ratio of ThT/Hoechst 33342 as normalized ThT fluorescence intensity. Mock was calculated as 1 to normalize for other conditions.
