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. 2022 Feb 28;12(3):325. doi: 10.3390/brainsci12030325

Figure 3.

Figure 3

Neonatal expression of Syn II rescues the enhancement in sEPSC frequency observed at Syn2 KO slices. (A) Representative recordings from WT, Syn2 KO, and AAV1.hSyn.Syn2-Turbo-GFP-injected Syn2 KO animals. Downward currents correspond to glutamatergic and upward currents correspond to GABAergic synaptic currents (holding potential -50 mV, see [31]). (B) ICV injections of AAV1.hSyn.Syn2-Turbo-GFP in Syn2 KO animals reduced the sEPSC frequency of the WT levels. N = 14 cells (at least 7 animals) per genotype. * p < 0.01, per ANOVA followed by Tukey’s test.