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. 2022 Mar 12;14(6):1459. doi: 10.3390/cancers14061459

Figure 1.

Figure 1

Notch signaling pathway. The interaction between Delta-like or Jagged-like ligands and NOTCH entails the activation of the signaling pathway. Whereas the extracellular domain (NECD) is split by a disintegrin and metalloproteinase (ADAM), the intracellular domain (NICD) is released by γ-secretase. Therefore, NICD translocates into the nucleus, displacing the co-repressor proteins (CoR) and promoting the target genes with the assistance of co-activators proteins (CoA) and CSL (CBF1/RBPJ-κ, suppressor of Hairless and LAG1). The common therapy target is by inhibiting γ-secretase; these types of drugs are collectively known as Gamma Secretase Inhibitors (GSIs). Nevertheless, blocking monoclonal antibodies (mAbs) is another strategy to inhibit Notch signaling. Figure were created with BioRender.com (accessed on 13 January 2022).