Table 1.
Effect of purmorphamine on the restoration of Smo-Shh level in 8-OH OCD.
| S.no. | Groups | Smo-Shh Protein Level | ||
|---|---|---|---|---|
| Brain Homogenate (nM/µg Protein) |
Blood Plasma (ng/mL) |
CSF (ng/mL) |
||
| 1. | Vehicle control | 11.89 ± 0.223 | 5.17 ± 0.030 | 2.49 ± 0.007 |
| 2. | Sham control | 11.65 ± 0.191 | 5.11 ± 0.019 | 2.51 ± 0.009 |
| 3. | PUR10 per se | 11.78 ± 0.187 | 5.12 ± 0.015 | 2.50 ± 0.009 |
| 4. | 8-OH-DPAT | 3.79 ± 0.102 * | 2.73 ± 0.054 * | 1.21 ± 0.011 * |
| 5. | 8-OH-DPAT + PUR5 | 4.78 ± 0.055 # | 3.23 ± 0.017 # | 1.46 ± 0.007 # |
| 6. | 8-OH-DPAT + PUR10 | 6.00 ± 0.070 #$ | 3.83 ± 0.024 #$ | 1.76 ± 0.007 #$ |
| 7. | 8-OH-DPAT + FLX10 | 7.63 ± 0.105 #β | 4.16 ± 0.011 #β | 2.06 ± 0.010 #β |
| 8. | 8-OH-DPAT + PUR10 + FLX10 | 9.05 ± 0.095 #@ | 4.65 ± 0.017 #@ | 2.25 ± 0.007 #@ |
Statistical analysis followed by one-way ANOVA (post-hoc Tukey’s test). Values expressed as mean ± SEM (n = 6 rats per group).* p < 0.01 v/s vehicle control, sham control and PUR10 per se; # p < 0.01 v/s 8-OH-DPAT; #$ p < 0.01 v/s 8-OH-DPAT + PUR5; #@ 8-OH-DPAT + FLX10; #β p < 0.01 v/s 8-OH-DPAT + PUR5 and 8-OH-DPAT + PUR10.