Table 3.
Effect of purmorphamine on TNF-α and IL-1β level in 8-OH OCD.
| S. no. | Groups | Cytokine Level | |||
|---|---|---|---|---|---|
| TNF-α | IL-1β | ||||
| Brain Homogenate (pg/mg Protein) |
Blood Plasma (ng/mL) |
Brain Homogenate (pg/mg Protein) |
Blood Plasma (ng/mL) |
||
| 1. | Vehicle control | 35.42 ± 0.242 | 4.49 ± 0.014 | 18.75 ± 0.126 | 14.47 ± 0.007 |
| 2. | Sham control | 35.80 ± 0.278 | 4.50 ± 0.014 | 18.92 ± 0.318 | 14.47 ± 0.010 |
| 3. | PUR10 per se | 35.53 ± 0.213 | 4.49 ± 0.011 | 18.67 ± 0.291 | 14.48 ± 0.007 |
| 4. | 8-OH-DPAT | 76.44 ± 0.725 * | 9.49 ± 0.009 * | 33.22 ± 0.198 * | 66.48 ± 0.008 * |
| 5. | 8-OH-DPAT + PUR5 | 67.40 ± 0.657 # | 8.47 ± 0.006 # | 28.35 ± 0.411 # | 55.39 ± 0.012 # |
| 6. | 8-OH-DPAT + PUR10 | 58.30 ± 0.221 #$ | 7.52 ± 0.009 #$ | 25.78 ± 0.223 #$ | 43.71 ± 0.014 #$ |
| 7. | 8-OH-DPAT + FLX10 | 50.01 ± 0.206 #β | 6.77 ± 0.009 #β | 23.08 ± 0.276 #β | 37.48 ± 0.014 #β |
| 8. | 8-OH-DPAT + PUR10 + FLX10 | 42.05 ± 0.170 #@ | 5.37 ± 0.009 #@ | 21.22 ± 0.279 #@ | 24.95 ± 0.008 #@ |
Statistical analysis followed by one-way ANOVA (post-hoc Tukey’s test). Values expressed as mean ± SEM (n = 6 rats per group). * p < 0.01 v/s vehicle control, sham control and PUR10 per se; # p < 0.01 v/s 8-OH-DPAT; #$ p < 0.01 v/s 8-OH-DPAT + PUR5; #β p < 0.01 v/s 8-OH-DPAT + PUR5 and 8-OH-DPAT + PUR10; #@ p < 0.01 v/s 8-OH-DPAT + FLX10.