Table 4.
Effect of purmorphamine on neurotransmitter levels in the brain samples of 8-OH OCD.
| S. no. | Groups | Neurotransmitters | ||
|---|---|---|---|---|
| Serotonin (ng/mg Protein) |
Glutamate (ng/mg Protein) |
Dopamine (ng/mg Protein) |
||
| 1. | Vehicle control | 44.24 ± 0.191 | 114.40 ± 0.208 | 95.42 ± 0.294 |
| 2. | Sham control | 44.26 ± 0.205 | 113.90 ± 0.333 | 95.74 ± 0.337 |
| 3. | PUR10 per se | 44.06 ± 0.197 | 113.90 ± 0.307 | 95.50 ± 0.335 |
| 4. | 8-OH-DPAT | 16.33 ± 0.290 * | 305.80 ± 0.316 * | 31.48 ± 0.394 * |
| 5. | 8-OH-DPAT + PUR5 | 22.34 ± 0.232 # | 214.30 ± 0.260 # | 43.10 ± 0.222 # |
| 6. | 8-OH-DPAT + PUR10 | 27.37 ± 0.223 #$ | 186.60 ± 0.248 #$ | 52.00 ± 0.392 #$ |
| 7. | 8-OH-DPAT + FLX10 | 32.87 ± 0.186 #β | 167.50 ± 0.639 #β | 63.05 ± 0.453 #β |
| 8. | 8-OH-DPAT + PUR10 + FLX10 | 38.23 ± 0.236 #@ | 142.20 ± 0.299 #@ | 74.19 ± 0.448 #@ |
Statistical analysis followed by one-way ANOVA (post-hoc Tukey’s test). Values expressed as mean ± SEM (n = 6 rats per group). * p < 0.01 v/s vehicle control, sham control and PUR10 per se; # p < 0.01 v/s 8-OH-DPAT; #$ p < 0.01 v/s 8-OH-DPAT + PUR5; #β p < 0.01 v/s 8-OH-DPAT + PUR5 and 8-OH-DPAT + PUR10; #@ p < 0.01 v/s 8-OH-DPAT + FLX10.