Table 4.

PFS and OS based on ctDNA and LB status.

PFS	Baseline (n = 47)
	ctDNA (+)	ctDNA (−)	p	Liquid (+)	Liquid (−)	p
N/Events	29/27	18/14		38/35	9/6
Median	6.0	15.9	0.012 (Figure 1)	6.0	18.6	0.020 (Figure S3)
Min–Max	0.8–52.8	2.6–46.4		0.8–52.8	3.0–44.8
95% C.I.	3.8–8.3	8.6–23.3		3.8–8.2	15.0–22.2
	Post-1 (n = 47)
	ctDNA (+)	ctDNA (−)	p	Liquid (+)	Liquid (−)	p
N/Events	13/13	34/28		23/22	24/19
Median	2.8	9.3	<0.001	3.3	8.2	0.056
Min–Max	0.8–5.9	2.6–52.8		0.8–52.8	2.6–44.8
95% C.I.	1.4–4.1	4.4–14.2		0.6–6.1	5.8–10.6
OS	Baseline (n = 47)
	ctDNA (+)	ctDNA (−)	p	Liquid (+)	Liquid (−)	p
N/Events	29/26	18/9		38/30	9/5
Median	13.5	30.9	0.005 (Figure 2A)	14.9	25.9	0.093
Min–Max	2.1–52.8	4.3–48.9		2.1–52.8	6.5–44.8
95% C.I.	10.4–16.6	14.6–47.2		12.3–17.5	13.5–38.3
1-year OS	58.6%	88.9%		62.9%	100%
	Post-1 (n = 47)
	ctDNA (+)	ctDNA (−)	p	Liquid (+)	Liquid (−)	p
N/Events	13/13	34/22		23/18	24/17
Median	4.7	22.0	<0.001 (Figure 2B)	14.3	20.2	0.269
Min–Max	2.1–15.2	4.3–52.8		2.1–52.8	4.3–48.9
95% C.I.	1.5–8.0	13.7–30.2		9.9–18.8	14.9–25.5
1-year OS	23.1%	88.1%		56.5%	83.1%
	EOT (n = 39)
	ctDNA (+)	ctDNA (−)	p	Liquid (+)	Liquid (−)	p
N/Events	24/23	15/10		29/25	10/8
Median	6.0	12.0	0.003 (Figure 2C)	7.1	10.0	0.250
Min–Max	0–20.1	0.2–27.7		0–27.7	0.2–27.0
95% C.I.	0–12.6	9.2–14.8		1.3–12.9	0–20.8
1-year OS	17.5%	46.7%		25.1%	40.0%

p-values marked with bold indicate statistically significant.