Table 5.

PFS and OS according to changes in ctDNA at Baseline, Post-1, and the EOT.

PFS	Baseline/Post-1
	+/+	−/−	p	+/+	+/−	p
N/Events	12/12	17/13		12/12	17/15
Median	2.3	15.9	<0.001 (Figure 3A)	2.3	8.0	<0.001 (Figure 3B)
Min–Max	0.8–5.9	2.6–46.4		0.8–5.9	2.8–52.8
95% C.I.	1.0–3.6	8.1–23.7		1.0–3.6	7.0–8.9
PFS	Post-1/EOT
	+/+	−/−	p	+/+	−/+	p
N/Events	12/12	15/15		12/12	12/12
Median	2.3	8.9	<0.001 (Figure 3C)	2.3	7.7	<0.001 (Figure 3D)
Min–Max	0.8–5.9	2.6–31.3		0.8–5.9	2.8–46.4
95% C.I.	1.0–3.6	6.5–11.3		1.0–3.6	6.9–8.5
OS	Baseline/Post-1
	+/+	−/−	p	+/+	+/−	p
N/Events	12/12	17/8		12/12	17/14
Median	4.2	NE	<0.001 (Figure 4A)	4.2	19.8	<0.001 (Figure 4B)
Min–Max	2.1–15.2	4.3–48.9		2.1–15.2	6.2–52.8
95% C.I.	3.1–5.3	-		3.1–5.3	14.2–25.3
1-year OS	16.7%	88.2%		16.7%	88.2%
OS	Post-1/EOT
	+/+	−/−	p	+/+	−/+	p
N/Events	12/12	15/10		12/12	12/11
Median	4.2	26.3	<0.001 (Figure 4C)	4.2	15.8	0.001 (Figure 4D)
Min-Max	2.1–15.2	4.5–48.9		2.1–15.2	4.3–47.8
95% C.I.	0–8.9	8.8–43.8		0–8.9	7.8–23.7
1-year OS	25.0%	86.7%		25.0%	83.3%

p-values marked with bold indicate statistically significant.