Table 6.

Univariate for PFS and OS.

Independent Factors	PFS		OS
	Hazard Ratio (95% Confidence Interval)	p	Hazard Ratio (95% Confidence Interval)	p
Performance status
PS 0	1 (reference)		1 (reference)
PS 1	1.2 (0.7–2.3)	0.534	1.8 (0.9–3.5)	0.094
Gender
Male	3.2 (1.5–6.6)	0.002	2.6 (1.3–5.2)	0.007
Female	1 (reference)		1 (reference)
Line of osimertinib
Second line	1.0 (0.5–1.7)	0.835	1.1 (0.6–2.2)	0.751
>Second line	1 (reference)		1 (reference)
T790M (plasma and/or tissue)
Detected	1.0 (0.5–2.0)	0.886	1.0 (0.5–2.0)	0.955
Not detected	1 (reference)		1 (reference)
Baseline ctDNA
Detected	2.3 (1.2–4.5)	0.015	2.9 (1.3–6.2)	0.007
Not detected	1 (reference)		1 (reference)

p-values marked with bold indicate statistically significant.