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. 2022 Mar 11;14(6):1457. doi: 10.3390/cancers14061457

Figure 1.

Figure 1

gCSCs are responsible for therapy failure and relapse. gCSCs represent a minority subpopulation of cancer cells within the tumor bulk that are characterized by unique properties that make them resistant to conventional therapies. As a consequence, they promote tumor recurrence and, with it, dismal prognosis.