Table 1.

gCSC regulators that have been associated with therapy resistance in GC.

Marker	Preclinical Setting		Clinical Setting
	CSCs In Vitro	Chemoresistance	Overexpression in GC	Association with Reduced Survival	Association with Poor Treatment Response
LGR5	[65]	[65,66,67]	[68,69]	[66,68,70]	[71,72]
CD44	[17,57,83,85,97]	[17,57,84,85,86,87,88,89,103]	[90,91,92,93,94,104,105]	[84,85,91,92,93,94,95,98,99,101,102,106]	[85,106]
CD133	[83,84,115]	[84,115,121,122]	[94,116,117,119]	[84,94,98,116,117,118,119,120]	[94,118,119]
HMMR	[132]	[132]	[131,132]	[131]	[131]
E2F1	[146]	[146,147,148]	[142,146,147]	[146,149]	[146,149]
ALDH	[156]	[156,157]	[158]	[160,161]	[161]