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. Author manuscript; available in PMC: 2023 Mar 1.
Published in final edited form as: Mass Spectrom Rev. 2021 Aug 15;42(2):674–705. doi: 10.1002/mas.21725

Figure 8. Expanded N-glycan IMS approaches for alternative clinical and laboratory sample types.

Figure 8.

A) N-glycan imaging mass spectrometry of tissue microarray cores correlates histopathologically-annotated tissue features with N-glycan analytes in a high-throughput fashion. B) N-glycan imaging of biofluids. Whole-serum N-glycan analysis examines amine reactive slide-captured serum total protein, while APB N-glycan imaging employs targeted N-glycan analysis of specific glycoproteins through high-affinity capture by slide-bound antibodies. C) N-glycan imaging mass spectrometry of cultured cells fixed to a glass microscope slide.