Fig 2. Comparison of the estimated SNP-based heritability and predictive performance across the 813 traits with significant PRSs.

The predictive performance (Nagelkerke’s pseudo-R² for 244 binary traits [left] and R² for 569 quantitative traits [right]) of the PRS models that only consider genetic variants are compared against the estimated SNP-based heritability. Both metrics are shown in observed scale and depend on the proportion of cases in the target and discovery cohorts. The solid gray lines represent y = x. We show the points on the bottom left corners in the inset plots. The error bars represent standard error. BMD: Bone mineral density.