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. 2022 Mar 10;12(3):429. doi: 10.3390/biom12030429

Figure 2.

Figure 2

Kv7 channel blockers inhibit cGMP-dependent relaxation. Traces illustrate pulmonary artery contraction to 1 μM phenylephrine (PE), followed by relaxation responses to increasing concentrations of riociguat (A) or sildenafil (B) applied cumulatively in control conditions (upper traces) and after incubation with 1 μM linopirdine (lower traces). Arrowheads indicate −log[dilator]. Concentration–response curves (bottom panel) are plotted in control conditions and after incubation with 1 μM Kv7 blocker as indicated. Riociguat n = 5 (control and linopirdine) or 3 (ODQ); sildenafil n = 4 (HMR1556 and XE991), 10 (control) or 11 (linopirdine).