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. 2022 Mar 10;12(3):429. doi: 10.3390/biom12030429

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Kv7 channel blockers inhibit endothelium-dependent vasodilation. Traces illustrate contraction to 1 μM phenylephrine (PE) followed by relaxation responses to carbachol (A) or A23187 (B), applied cumulatively at the concentrations indicated by the arrowheads (−log[dilator]), in control conditions (upper traces) and after incubation with 1μM XE991 (lower traces). Graphs show concentration–response curves to carbachol (A, n = 6) and A23187 (B, n = 8–9) in control conditions and after incubation with 1 μM XE991, linopirdine or HMR1556 as indicated.