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. 2022 Mar 10;12(3):429. doi: 10.3390/biom12030429

Figure 5.

Figure 5

Kv7 channel blockers inhibit treprostinil-induced relaxation. Traces illustrate contraction to 1 μM phenylephrine (PE) followed by relaxation after cumulative addition of 0.1 nM–1 μM treprostinil in control conditions (A(i)) and after adding 1 μM XE991 (A(ii)). Arrowheads indicate -log[treprostinil]. Concentration–relaxation curves (A(iii)) are compared in control conditions and after adding a Kv7 channel blocker (1 μM), as indicated (n = 6 in each condition). (B) Concentration–response curves to GW0742 in the absence and presence of 1 μM XE991 (n = 8). Treprostinil concentration–response curves are compared in the absence and presence of 1 μM XE991 after blocking NO synthase with 100 μM L-NAME (C; n = 8) and with additional block of EP receptors with 10 μM SC-51322 (D; n = 5).