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. 2022 Feb 28;12(3):328. doi: 10.3390/brainsci12030328

Figure 1.

Figure 1

Lymphocyte migration across the BCSFB. Lymphocytes expressing PSGL-1 interact with P-selectin constitutively expressed on the endothelial cell layer of the CP. In the stroma, lymphocytes expressing chemokine receptors (CKR) matching the chemokines present at the CP are attracted to migrate across the ependymal cell layer. In the CSF of the CP, lymphocytes can either attach via interactions between integrins LFA-1 and VLA-4 with the respective cell adhesion molecules ICAM-1 and VCAM-1, or remain in the CSF.