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Proposed model for NRF2 role in cancer cell chemosensitivity and p53 activity. Hyperactivation of NRF2 (by SFN) counteracts the CDDP-induced DNA damage, impairing the p53 activity and reducing cell death; ZnCl2 supplementation counteracts the effect of SFN/NRF2 rescuing the DNA damage, p53 activity, and cell death, induced by CDDP.
