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. 2022 Mar 10;14(6):1433. doi: 10.3390/cancers14061433

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Schematic representation of the interplay between mitochondria and the cytoskeleton. (A) The intrinsic forces generated from actin polymerization upon INF2 and spire1 binding can facilitate DRP1 recruitment to the mitochondria, therefore promoting mitochondria fission. (B) Cofilin, cortactin, and actin related protein 2/3 (Arp2/3) complexes regulate actin filaments accumulation on the outer mitochondrial membrane, which can initiate mitochondria fission. (C) Cofilin localization at the mitochondria can reduce the mitochondria membrane potential and trigger mitophagy mediated by Pink1/park2.