Figure 3.

Schematic representation of the effect of ECM/Mitochondria interplay on cell migration. (A) Stiff ECM can enhance glutamine uptake, which in turn feeds the TCA cycle. (B) Random 3D ECM can increase OXPHOS activity and the ATP:ADP ratio. (C) Soft ECM can trigger mitochondria fission in a Kindlin2-dependent manner, while stiff ECM can trigger mitochondria fusion in a PINCH1-dependent manner. (D) Stiff ECM can increase CKB expression and activity in a YAP signaling-dependent fashion, which in turn increases the OXPHOS activity and mitochondria fusion.