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. 2022 Mar 10;14(6):1433. doi: 10.3390/cancers14061433

Figure 4.

Figure 4

Schematic representation of the crosstalk between the ECM and mitochondria function. (A) ECM detachment can trigger the release of cytochrome C and Smac/Diablo from the mitochondria, resulting in necrosis. (B) ECM detachment can activate RIPK1 which in turn increases the production of ROS, leading to mitophagy. (C) OXPHOS deficiency results in increased MMP1 and degreased TIPM1 levels. (D) ROS production can be increased via the downregulation of TMEM126A, a mitochondria transmembrane receptor, resulting in reduced expression of ECM and cell adhesion genes.