Table 2.
Representative Proteomics-based Biomarkers for GC.
| Sample Sources | Labeling and MS Methods | Proposed Proteomics-Based Biomarkers (Specificity:Sensitivity %:%) | References |
|---|---|---|---|
| GC cell lines | MALDI-TOF MS | CIP2A, PIK3CB | [93] |
| Plasma and cell lines | iTRAQ | DEK (79:70.4) | [84] |
| Mice and cell lines | iTRAQ/ LC-MS/MS | ITIH3 (66:96) | [91] |
| Gastric juice, Plasma, Serum | LC-MS/MS | ANK1 (86.7:46.7), FOLR2 (80:60), Gastric juice free amino acid (89.2:85.1), GRN, LILRA2 (93.3:60), MGP (80:73.3), NBL1 (53.3:80), OAF (100:46.7), PCSK9 (80:60), PSTPIP2 (53.3:73), RPS27A (66.7:86.7), SHBG, SOD1 (46.7:93.3), and TRIM3 | [78,81,82,88,92] |
| Gastric fluids, Serum, tissues | MALDI-TOF MS, 2D-DIGE MALDI-TOF MS, SELDI-TOF MS | AAT, CIP2A, GIF, LPCAT1, PIK3CB, S100A9, peaks at Da of 2863 (75:75), 2953 (85:85), 1945 (90:90), and 2082 (75:75), and peaks at m/z 5910 (91.3:86.3), 5342 (80.6:80.3), 6439 (70.3:73.3), 2873 (91.57:93.49), 3163 (91.57:93.49), 4526 (91.57:93.49), 5762 (91.57:93.49), 6121 (91.57:93.49), and 7778 (91.57:93.49) | [76,77,80,83,85,93] |
| Tissue and plasma, mouse plasma | iTRAQ, 2D-DIGE LS/MS, LC-ESI-MS/MS | ANXA1, FABP1 (77.1:61.4), FASN (77.1:61.4), Fibulin-5, GGCT (60.7:63.1), GLS1 (81:75.6), HDAC1 (63.2:61.8), MTA2 (55.3:57.9), NNMT, and UQCRC1 | [84,86,87,89,90,91] |