Table A4.

Dosing of best supportive care therapies.

Chemotherapy	Admin Route	mg/m2/day	Frequency	mg/Unit	Cost/Unit	Source
Rituximab	IV	375	Q4W for 6 cycles [54]	100	482.31	Ontario EAP [47]
Bendamustine	IV	70	Q4W 2 days for 6 cycles [54]	25	312.50	pCODR economic review of Bendamustine [48]
Lenalidomide	Oral	25	21 days on, 7 off [53]	25	424.00	Ontario EAP [47]
Bortezomib	IV	1.3	Q3W 4 days, 9 cycles [51]	3.5	1402.42	pCODR economic review of Daratumumab [49]
Anthracycline	IV	50	Q3W [52]	1	5.05	pCODR economic review of Pertuzumab-Trastuzumab [50]

Abbreviations: BSC, best supportive care; EAP, Exceptional Access Program; IV, intravenous; pCODR, pan-Canadian Oncology Drug Review; Q3W, every 3 weeks; Q4W, every 4 weeks.