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. 2022 Mar 24;17(3):e0266028. doi: 10.1371/journal.pone.0266028

Table 2. Presence of comorbidities, signs, and symptoms associated with vaccine administration.

Total Male Female P-value
Did you have any medical condition that may aggravate COVID-19 illness 159 (31.7) 89 (17.7) 70 (13.9) P>0.05
    Diabetes 68 (13.5) 41 (8.2) 27 (5.4) P>0.05
    Hypertension 82 (16.3) 47 (9.4) 35 (7.0) P>0.05
    Arthritis/Joint Pain 12 (2.4) 8 (1.6) 4 (0.8) P>0.05
    Obesity 34 (6.8) 8 (1.6) 26 (5.2) P<0.001
    Asthma 13 (2.6) 6 (1.2) 7 (1.4) P>0.05
    Allergies 6 (1.2) 5 (1.0) 1 (0.2) P>0.05
    Dementia 8 (1.6) 5 (1.0) 3 (0.6) P>0.05
    Other conditions 14 (2.8) 7 (1.4) 7 (1.4) P>0.05
    None 343 (68.3) 187 (37.3) 156 (31.1) P>0.05
Smoking Status
    Non Smoker 486 (96.8) 261 (52.0) 225 (44.8) P>0.05
    Smoker 16 (3.2) 16 (3.2) 0 (0.0) P<0.001
Did you experience any symptoms after vaccination administration?
    No 222 (44.2) 139 (27.7) 83 (16.5)
    Yes 280 (55.8) 138 (27.5) 142 (28.3) P = 0.003a
On site of injection 256 (51.0) 121 (24.1) 135 (26.9) P<0.001 a
    Pain 250 (49.8) 117 (23.3) 133 (26.5) P<0.001a
    Swelling 123 (24.5) 58 (11.6) 65 (12.9) P = 0.039a
    Redness 67 (13.3) 34 (6.8) 33 (6.6) P>0.05
In Whole Body 278 (55.4) 137 (27.3) 141 (28.1) P = 0.003 a
    Sore throat 30 (6.0) 15 (3.0) 15 (3.0) P>0.05
    Headache 42 (8.4) 18 (3.6) 24 (4.8) P>0.05
    Asthenia 216 (43.0) 108 (21.5) 108 (21.5) P = 0.043a
    Muscle Pain 148 (29.5) 72 (14.3) 76 (15.1) P>0.05
    Chills 6 (1.2) 2 (0.4) 4 (0.8) P>0.05
    Fever 33 (6.6) 26 (5.2) 7 (1.4) P = 0.005b
    Nausea/Vomiting 49 (9.8) 19 (3.8) 30 (6.0) P = 0.015b
    Stomach Upset 29 (5.8) 6 (1.2) 23 (4.6) P<0.001a
    Vertigo 70 (13.9) 39 (7.8) 31 (6.2) P>0.05
    Restlessness 3 (0.6) 0 (0.0) 3 (0.6) P>0.05
    Dry throat 5 (1.0) 2 (0.4) 3 (0.6) P>0.05
Quite Rare Symptoms 50 (10.0) 31 (6.2) 19 (3.8) P>0.05
    Depression 26 (5.2) 19 (3.8) 7 (1.4) P>0.05
    Anxiety 26 (5.2) 19 (3.8) 7 (1.4) P>0.05
    Mood swing 26 (5.2) 19 (3.8) 7 (1.4) P>0.05
    Rash 8 (1.6) 2 (0.4) 6 (1.2) P>0.05
    Breathing issues 3 (0.6) 3 (0.6) 0 (0.0) P>0.05
    Hair loss 8 (1.6) 2 (0.4) 6 (1.2) P>0.05
    CVD 3 (0.6) 2 (0.4) 1 (0.2) P>0.05
    Sleep disturbance 3 (0.6) 1 (0.2) 2 (0.4) P>0.05
    Loss of concentration 3 (0.6) 1 (0.2) 2 (0.4) P>0.05
The illness affected after COVID-19 vaccination
    No prior disease/Completely Healthy 329 (65.5) 196 (39.0) 133 (26.5) P = 0.009b
    Illness not affected at all 140 (27.9) 62 (12.4) 78 (15.5) P = 0.009a
    Yes, illness aggravated after vaccine 33 (6.6) 19 (3.8) 14 (2.8) P = 0.009b
How much do you think your illness increased?
    Less than 50% 29 (5.8) 16 (3.2) 13 (2.6) P>0.05
    More than 50% 4 (0.8) 3 (0.6) 1 (0.2) P = 0.019a
Dose of vaccine which resulted in more severe symptoms
    First dose 190 (37.8) 94 (18.7) 96 (19.1) P>0.05
    Second dose 69 (13.7) 39 (7.8) 30 (6.0) P>0.05
    Both doses 4 (0.8) 3 (0.6) 1 (0.2) P>0.05
    None of them 239 (47.6) 141 (28.1) 98 (19.5) P>0.05
How many days later you recovered completely from symptoms?
    Within 1 week 103 (20.5) 53 (10.6) 50 (10.0) P>0.05
    Within 2 weeks 39 (7.8) 18 (3.6) 21 (4.2) P>0.05
    Within 4 weeks 10 (2.0) 4 (0.8) 6 (1.2) P>0.05
    More than a month 11 (2.2) 7 (1.4) 4 (0.8) P>0.05