Figure 1.

Glycolysis. Glycolytic enzymes and metabolites are depicted as well as some of the pathways that branch off or that modulate steps in the glycolytic metabolism (see text for more details). Green arrows refer to steps that are inherent to glycolysis, red arrows to reactions that branch off or modulate glycolysis. ALDO, aldolase, fructose-bisphosphate; ENO, enolase; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; GPI, glucose 6-phosphate isomerase; HK, hexokinase; LDH, lactate dehydrogenase; PDH, pyruvate dehydrogenase; PDK, pyruvate dehydrogenase kinase; PFK-1, phosphofructokinase-1; PFK-2, phosphofructokinase-2 (including the isoforms 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) and PFKFB4); PGK, phosphoglycerate kinase; PGM, phosphoglycerate mutase; PK, pyruvate kinase; PPP, pentose phosphate pathway; TPI, triosephosphate isomerase.