Table 1.

Gene loci identified for myopia from linkage analysis and sequencing studies.

Locus	Location	Gene	Inheritance	Ethnicity	Reference
MYP1	Xq28	OPN1LW, OPN1MW	X-linked	Danish	Schwartz et al., 1990 [32]
MYP2	18p11.31	n.r.	AD	Chinese and European	Young 1998, Young 2001 [33,34]
MYP3	12q21-q23	n.r.	AD	German/Italian	Young 1998 [35]
MYP5	17q21-q22	n.r.	AD	English/Canadian	Paluru et al., 2003 [36]
MYP6	22q13.33	SCO2	AD	Ashkenazi Jewish	Stambolian et al., 2004 [37]
MYP7	11p13	n.r.	Multifactorial	Caucasian	Hammond et al., 2004 [38]
MYP8	3q26	n.r.	Multifactorial	Caucasian	Hammond et al., 2004 [38]
MYP9	4q12	n.r.	Multifactorial	Caucasian	Hammond et al., 2004 [38]
MYP10	8p23	n.r.	Multifactorial	Caucasian	Hammond et al., 2004 [38]
MYP11	4q22-q27	n.r.	AD	Chinese	Zhang et al., 2005 [39]
MYP12	2q37.1	n.r.	AD	Northern European	Paluru et al., 2005 [40]
MYP13	Xq23-q27.2	n.r.	X-linked	Chinese	Zhang et al., 2006 [41]
MYP14	1q36	n.r.	n.r.	Ashkenazi Jewish	Wojciechowski et al., 2006 [42]
MYP15	10q21.1	n.r.	AD	Caucasian	Nallasamy et al., 2007 [43]
MYP16	5p15.33-p15.2	n.r.	AD	Chinese	Lam et al., 2008 [24]
MYP17	7p15	n.r.	AD	French and Algerian	Paget et al., 2008 [44]
MYP18	14q22.1-q24.2	n.r.	AR	Chinese	Yang et al., 2009 [45]
MYP19	5p13.3-p15.1	n.r.	AD	Chinese	Ma et al., 2010 [46]
MYP20	13q12.12	n.r.	AD	Chinese	Shi et al., 2011 [47]
MYP21	1p22.2	ZNF644	AD	Chinese, Caucasian and African American	Shi et al., 2011 Tran-Viet et al., 2012 [48,49]
MYP22	4q35.1	CCDC111	AD	Chinese	Zhao et al. 2013 [50]
MYP23	4p16.3	LRPAP1	AR	Saudi Arabian and Chinese	Aldahmesh et al. 2013 Jiang et al. 2015 [51,52]
MYP24	12q13.3	SLC39A5	AD	Chinese	Guo et al., 2014 [53]
MYP25	5q31.1	P4HA2	AD	Chinese	Guo et al., 2015 [54]
MYP26	Xq13.1	ARR3	X-linked	Chinese	Xiao et al., 2016 [55]
MYP27	8q24.3	CPSF1	AD	Chinese	Ouyang et al., 2019 [56]

* MYP4 was merged into MYP17. AD = autosomal dominant; AR = autosomal recessive; n.r. = not reported.