. 2022 Mar 9;9(3):382. doi: 10.3390/children9030382

Table 2.

Genome-wide association studies in myopia and top findings.

First Author	Publication Date *	Phenotype	Discovery Stage		Replication Stage		Genes/Loci **
First Author	Publication Date *	Phenotype	Cases	Controls	Cases	Controls	Genes/Loci **
Nakanishi H. [86]	25 September 2009	High myopia	297 Japanese ancestry	934 Japanese ancestry	533 Japanese ancestry	977 Japanese ancestry	BLID-LOC399959
Li Y.J. [57]	20 November 2010	High myopia	65 children and 222 adults of Singaporean Chinese	238 children and 435 adults of Singaporean Chinese	959 Japanese ancestry	2128 Japanese ancestry	CTNND2
Li Z. [88]	19 April 2011	High myopia	102 Chinese ancestry	335 Chinese ancestry	2891 Chinese ancestry	10,071 Chinese ancestry	4q25
Shi Y. [47]	2 June 2011	High myopia	419 Chinese ancestry	669 Chinese ancestry	2803 Chinese ancestry	5642 Chinese ancestry	MIPEP
Meng W. [90]	9 October 2012	High myopia	187 European ancestry	1064 European ancestry	NA	NA	CDH8, DHX15, SAMD5, LINC02434, PSMD10P2, KNG1, RNU6-1129P, GNPATP, RNU6-66P, RNU4-10P, LINC00603, SPATA22, ASPA and 53 genes/loci
Shi Y. [91]	28 February 2013	High myopia	665 Han Chinese ancestry	960 Han Chinese ancestry	2128 Han Chinese ancestry	3683 Han Chinese ancestry	SNTB1, PCDH1, VIPR2
Khor C.C. [92]	9 August 2013	High myopia	1603 East Asian ancestry	3427 East Asian ancestry	1241 East Asian ancestry	3559 East Asian ancestry	SNTB1, ZFHX1B
Simpson C.L. [93]	18 September 2014	Myopia	3923 European ancestry	11,696 European ancestry	4331 European ancestry	4169 European ancestry	LAMA2, GJD2, RBFOX1
Pickrell J.K. [94]	16 May 2016	Myopia	106,086 European ancestry	85,757 European ancestry	NA	NA	LAMA2, LRRC4C, GJD2, RDH5, PRSS56, ZMAT4, DLG2, PCCA-DT, NDUFA12P1, SHISA6, BMP3 and 41 genes/loci
Meguro A. [95]	16 May 2020	High myopia	1632 Japanese ancestry	1586 Japanese ancestry	881 East Asian ancestry	9946 East and Southeast Asian ancestry	HIVEP3, NFASC, ZC3H11B, CNTN4-CNTN6, FRMD4B, LINC02418, GJD2, RASGRF1, AKAP13

* Epub data or the earliest publication data; ** If the study reported more than 10 significant genes/loci, then only the name of top 10 genes/loci were shown in the table.