Table 1.
Frequency of occurrence and cumulative percentage distribution of ceftobiprole MICs for all European clinical isolates tested (2016–19)
| Organism (number of isolates tested) | Number of isolates (cumulative %) inhibited as function of ceftobiprole MIC, mg/L | Susceptibility, % | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| ≤0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | >8 | ||
| Gram-positive bacteria | ||||||||||
| S. aureus (7000) | 3 (0.0) | 30 (0.5) | 1291 (18.9) | 2631 (56.5) | 2043 (85.7) | 983 (99.7) | 19 (100) | 99.7 | ||
| MSSA (3498) | 2 (0.1) | 30 (0.9) | 1278 (37.4) | 2175 (99.6) | 13 (100) | 100 | ||||
| MRSA (3502) | 1 (0.0) | 0 (0.0) | 13 (0.4) | 456 (13.4) | 2030 (71.4) | 983 (99.5) | 19 (100) | 99.5 | ||
| S. pneumoniae (3007) | 2411 (80.2) | 74 (82.6) | 153 (87.7) | 303 (97.8) | 64 (99.9) | 1 (99.9) | 1 (100) | 97.8 | ||
| Penicillin susceptible (953) | 953 (100) | 100 | ||||||||
| Penicillin intermediatea (702) | 259 (36.9) | 69 (46.7) | 142 (67.0) | 211 (97.0) | 21 (100) | 97.0 | ||||
| Penicillin resistant (148) | 1 (0.7) | 10 (7.4) | 92 (69.6) | 43 (98.6) | 1 (99.3) | 1 (100) | 69.6 | |||
| Gram-negative bacteria | ||||||||||
| Enterobacterales (7197) | 4853 (67.4) | 402 (73.0) | 237 (76.3) | 162 (78.6) | 104 (80.0) | 65 (80.9) | 56 (81.7) | 47 (82.3) | 1271 (100) | 76.3 |
| Ceftazidime susceptibleb (5791) | 4714 (81.4) | 362 (87.7) | 208 (91.3) | 143 (93.7) | 77 (95.0) | 26 (95.5) | 14 (95.7) | 12 (95.9) | 235 (100) | 91.3 |
| Ceftazidime resistant (1406) | 139 (9.9) | 40 (12.7) | 29 (14.8) | 19 (16.1) | 27 (18.1) | 39 (20.8) | 42 (23.8) | 35 (26.3) | 1036 (100) | 14.8 |
| Enterobacter spp. (822) | 545 (66.3) | 44 (71.7) | 19 (74.0) | 11 (75.3) | 18 (77.5) | 32 (81.4) | 34 (85.5) | 28 (88.9) | 91 (100) | 74.0 |
| Ceftazidime susceptibleb (555) | 499 (89.9) | 31 (95.5) | 12 (97.7) | 3 (98.2) | 1 (98.4) | 1 (98.6) | 8 (100) | 97.7 | ||
| Ceftazidime resistant (267) | 46 (17.2) | 13 (22.1) | 7 (24.7) | 8 (27.7) | 17 (34.1) | 32 (46.1) | 34 (58.8) | 27 (68.9) | 83 (100) | 24.7 |
| E. coli (1948) | 1558 (80.0) | 45 (82.3) | 25 (83.6) | 8 (84.0) | 2 (84.1) | 1 (84.1) | 3 (84.3) | 4 (84.5) | 302 (100) | 83.6 |
| Ceftazidime susceptibleb (1712) | 1546 (90.3) | 42 (92.8) | 22 (94.0) | 7 (94.5) | 1 (94.5) | 1 (94.6) | 3 (94.7) | 3 (94.9) | 87 (100) | 94.0 |
| Ceftazidime resistant (236) | 12 (5.1) | 3 (6.4) | 3 (7.6) | 1 (8.1) | 1 (8.5) | 1 (8.9) | 215 (100) | 7.6 | ||
| Klebsiella spp. (3191) | 1843 (57.8) | 160 (62.8) | 132 (66.9) | 115 (70.5) | 68 (72.6) | 30 (73.6) | 12 (74.0) | 11 (74.3) | 820 (100) | 66.9 |
| Ceftazidime susceptibleb (2358) | 1763 (74.8) | 144 (80.9) | 125 (86.2) | 111 (90.9) | 63 (93.6) | 23 (94.5) | 8 (94.9) | 7 (95.2) | 114 (100) | 86.2 |
| Ceftazidime resistant (833) | 80 (9.6) | 16 (11.5) | 7 (12.4) | 4 (12.9) | 5 (13.4) | 7 (14.3) | 4 (14.8) | 4 (15.3) | 706 (100) | 12.4 |
| K. pneumoniae (2223) | 1342 (60.4) | 75 (63.7) | 28 (65.0) | 15 (65.7) | 21 (66.6) | 14 (67.3) | 7 (67.6) | 6 (67.8) | 715 (100) | 65.0 |
| Ceftazidime susceptibleb (1513) | 1335 (88.2) | 70 (92.9) | 27 (94.6) | 14 (95.6) | 19 (96.8) | 8 (97.4) | 4 (97.6) | 2 (97.8) | 34 (100) | 94.7 |
| Ceftazidime resistant (710) | 7 (1.0) | 5 (1.7) | 1 (1.8) | 1 (2.0) | 2 (2.3) | 6 (3.1) | 3 (3.5) | 4 (4.1) | 681 (100) | 1.8 |
| Serratia marcescens (618) | 380 (61.5) | 133 (83.0) | 43 (90.0) | 22 (93.5) | 12 (95.5) | 2 (95.8) | 3 (96.3) | 2 (96.6) | 21 (100) | 90.0 |
| Ceftazidime susceptibleb (602) | 380 (63.1) | 133 (85.2) | 42 (92.2) | 22 (95.8) | 12 (97.8) | 2 (98.2) | 2 (98.5) | 1 (98.7) | 8 (100) | 92.2 |
| Ceftazidime resistant (16) | 1 (6.3) | 1 (12.5) | 1 (18.8) | 13 (100) | 6.3 | |||||
| P. mirabilis (618) | 527 (85.3) | 20 (88.5) | 18 (91.4) | 6 (92.4) | 4 (93.0) | 4 (93.7) | 2 (94.0) | 37 (100) | 91.4 | |
| Ceftazidime susceptibleb (564) | 526 (93.3) | 12 (95.4) | 7 (96.6) | 1 (96.8) | 18 (100) | 96.6 | ||||
| Ceftazidime resistant (54) | 1 (1.9) | 8 (16.7) | 11 (37.0) | 6 (48.1) | 4 (55.6) | 3 (61.1) | 2 (64.8) | 19 (100) | 37.0 | |
| P. aeruginosa (2191) | 2 (0.1) | 2 (0.2) | 5 (0.4) | 48 (2.6) | 257 (14.3) | 700 (46.3) | 422 (65.5) | 311 (79.7) | 444 (100) | 65.5 |
| Imipenem non-resistant (1609) | 2 (0.1) | 2 (0.2) | 5 (0.6) | 46 (3.4) | 241 (18.4) | 642 (58.3) | 339 (79.4) | 198 (91.7) | 134 (100) | 79.4 |
| Imipenem resistant (582) | 2 (0.3) | 16 (3.1) | 58 (13.1) | 83 (27.3) | 113 (46.7) | 310 (100) | 27.3 | |||
| Ceftazidime susceptibleb (1373) | 2 (0.1) | 2 (0.3) | 5 (0.7) | 46 (4.0) | 239 (21.4) | 596 (64.8) | 245 (82.7) | 134 (92.6) | 104 (100) | 82.7 |
| Ceftazidime resistant (818) | 2 (0.2) | 18 (2.4) | 104 (15.2) | 177 (36.8) | 177 (58.4) | 340 (100) | 36.8 | |||
| H. influenzae (605) | 368 (60.8) | 108 (78.7) | 50 (86.9) | 30 (91.9) | 29 (96.7) | 20 (100) | 100 | |||
| Ampicillin susceptible (451) | 285 (63.2) | 78 (80.5) | 33 (87.8) | 23 (92.9) | 13 (95.8) | 19 (100) | 100 | |||
| Ampicillin resistant (154) | 83 (53.9) | 30 (73.4) | 17 (84.4) | 7 (89.0) | 2 (90.3) | 15 (100) | 100 | |||
| Ampicillin susceptible, AMC resistant (41) | 10 (24.4) | 18 (68.3) | 6 (82.9) | 5 (95.1) | 2 (100) | 100 | ||||
AMC, amoxicillin/clavulanic acid.
a
Referred as susceptible, increased exposure.
b
Includes susceptible plus susceptible at increased exposure.