Table 5.

Comparison performance of HT-CAD in different subgroups by thyroid hormone levels

	Accuracy (95% CI)	Sensitivity (95% CI)	Specificity (95% CI)	PPV	NPV	AUC	F1 (avg)	κ value
Performance
All	0.892 (0.881-0.902)	0.890 (0.868-0.911)	0.895 (0.874-0.913)	0.904	0.880	0.940	0.892	0.784
Group A (with hyperthyroidism)	0.871 (0.861-0.880)	0.911 (0.893-0.929)	0.674 (0.656-0.692)	0.922	0.660	0.861	0.920	0.586
Group B (with hypothyroidism)	0.888 (0.877-0.897)	0.883 (0.861-0.905)	0.874 (0.854-0.891)	0.950	0.754	0.931	0.920	0.731
Group C (with euthyroidism)	0.894 (0.884-0.902)	0.896 (0.874-0.915)	0.908 (0.889-0.925)	0.879	0.908	0.947	0.887	0.787
P-value
All vs Group A	<0.001	<0.001	<0.001				—	—
All vs Group B	0.384	0.219	0.003				—	—
All vs Group C	0.625	0.247	0.084				—	—
Group A vs Group C	<0.001	<0.001	<0.001				—	—
Group B vs Group C	0.289	0.084	<0.001				—	—
Group A vs Group B	0.005	<0.001	<0.001				—	—

Abbreviations: AUC, area under the curve; κ value, Fleiss’s κ value; NPV, negative predictive value; PPV, positive predictive value.