Table 5.
Volumes of amygdalae and hippocampi in premenopausal women with newly diagnosed Graves disease and matched controls
| A, Comparison of patients at inclusion and patients at 15 mo in euthyroidism | ||||
|---|---|---|---|---|
| Mean ± SD non–ICV-normalized volume, mm3 | ||||
| Patients at inclusion (N = 47c) | Patients at 15 mo (N = 47c) |
Difference in mean, mm3 | P a | |
| Left amygdala | 1123.1 ± 154.9 | 1201.7 ± 141.8 | –78.6 | 3.0e-4 |
| Right amygdala | 997.1 ± 160.7 | 1094.7 ± 137.9 | –97.6 | 1.7e-6 |
| Left hippocampus | 1682.1 ± 191.1 | 1761.6 ± 189.8 | –79.5 | 1.3e-4 |
| Right hippocampus | 1797.5 ± 220.6 | 1885.5 ± 199.4 | –88.0 | 1.2e-5 |
| B, Comparison of patients at 15 mo and controls at inclusion | ||||
| Mean ± SD ICV-normalized volume, mm 3 | ||||
|
Patients at 15 mo
(N = 48) |
Controls at inclusion (N = 56) | Difference in mean, mm 3 | P b | |
| Left amygdala | 1207.1 ± 132.2 | 1266.5 ± 140.3 | –59.4 | .029 |
| Right amygdala | 1099.9 ± 126.5 | 1146.1 ± 114.9 | –46.2 | .054 |
| Left hippocampus | 1766.2 ± 179.5 | 1759.9 ± 177.2 | 6.3 | .858 |
| Right hippocampus | 1892.6 ± 173.5 | 1889.6 ± 176.8 | 3.0 | .932 |
Segmentation was performed with the MAPER (multiatlas propagation with enhanced registration) automatic method. Owing to dropouts, 48 patients were included. Nonintracranial volume (ICV)-normalized volumes were used for longitudinal comparisons in patients, and ICV-normalized volumes were used for comparisons between patients and controls. P values less than .05 are shown in bold.
a Paired t test.
b Unpaired t test.
c Only 47 of the 48 patients remaining at 15 months had a magnetic resonance scan at baseline.