Table 3.
Common deregulated genes from nCounter and total RNA-Seq analyses.
| # | Gene ID | Gene Name | Main Function | p-Value |
|---|---|---|---|---|
| Common upregulated genes | ||||
| 1 | PKM | Pyruvate Kinase M1/2 | Catalyzes the last step within glycolysis, the dephosphorylation of phosphoenolpyruvate to pyruvate. | p < 0.01 |
| 2 | IFIT1 | Interferon Induced Protein with Tetratricopeptide Repeats 1 | Acts as a sensor of viral single-stranded RNAs and inhibits expression of viral messenger RNAs. | p < 0.01 |
| 3 | OAS1 | 2′-5′-Oligoadenylate Synthetase 1 | Activates latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. | p < 0.01 |
| 4 | C2 | Complement C2 | Functions as part of the classical pathway of the complement system. | p < 0.01 |
| 5 | CFP | Complement Factor B | Functions as part of the alternate pathway of the complement system. | p < 0.01 |
| 6 | SIGLEC1 | Sialic Acid Binding Ig Like Lectin 1 | Mediates sialic-acid dependent binding of macrophages to lymphocytes, granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. | p < 0.01 |
| 7 | CD163 | Cluster of Differentiation 163 | Is involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages. Acts as an innate immune sensor for bacteria. |
p < 0.01 |
| 8 | ISG15 | Interferon-stimulated gene 15 | Plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. | p < 0.01 |
| 9 | CTSC | Cathepsin C | Functions as a central coordinator for activation of many serine proteases in immune/inflammatory cells. | p < 0.01 |
| 10 | RSAD2 | Radical S-Adenosyl Methionine Domain Containing 2 | Plays a major role in the cell antiviral state induced by type I and type II interferon | p < 0.01 |
| 11 | MS4A4A | Membrane Spanning 4-Domains A4A | May be involved in signal transduction as a component of a multimeric receptor complex. | p < 0.01 |
| Common downregulated genes | ||||
| 12 | TCF4 | Transcription Factor 4 | Acts as a transcription factor which binds to the immunoglobulin enhancer mu-E5/kappa-E2 motif. | p < 0.01 |
| 13 | SNCA | Synuclein Alpha | Involved in synaptic vesicle recycling. | p < 0.01 |
| 14 | TGFB3 | Transforming Growth Factor Beta 3 | A cytokine involved in cell differentiation, embryogenesis and development. | p < 0.01 |
| 15 | CD83 | Cluster of Differentiation 83 | May play a significant role in antigen presentation. | p < 0.01 |
| 16 | DLL4 | Delta Like Canonical Notch Ligand 4 | Encodes Notch ligands. | p < 0.01 |