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. 2022 Mar 24;18(3):e1010378. doi: 10.1371/journal.ppat.1010378

Fig 3. Impaired effector functions of CD73+CD8+ T cells compared to CD73-CD8+ T cells in PBMCs of HIV-infected individuals.

Fig 3

(A) Representative flow cytometry plots, and (B) Cumulative data of TNF-α, IFN-γ, and IL-2 expression in CD73+ versus CD73-CD8 T cells upon stimulation of PBMCs from HIV-infected individuals with anti-CD3/CD28. (C) Cumulative data of TNF-α, and (D) IFN-γ expression in CD73+ versus CD73- in different subsets of CD8+ T cells of HIV-infected individuals. (E-G) Fold regulation of TNF-α, IFN-γ, and IL-2 genes in CD73+CD8+ T cells relative to CD73- CD8+ T cells of HIV-infected individuals quantified by qPCR. (H) Gating strategy and the representative plots showing CD73+ cells among CD137+ CD8+ T cells compared to CD137-CD8+ T cells, and (I) Cumulative data of TNF-α and IFN-γ expression in CD73+ versus CD73- CD137+ CD8+ T cells upon stimulation of PBMCs from HIV-infected individuals with the Gag peptide pool. Each point represents one HIV-infected individual. Data are obtained from multiple independent experiments. Each dot represents data from an individual human subject. Statistical analysis determined by the Mann-Whitney U-test (B, C, D-G and J) with significance indicated. ns, no significant. n: reflects the number of samples.