TABLE 2.
Cytotoxic activity toward human cancer cell lines (KB and HeLa) and antiprotozoal selectivity indexa of some Strychnos alkaloids
| Compound | IC50 (μM) | Selectivity indexa
|
|
|---|---|---|---|
| FCA | W2 | ||
| Dihydrousambarensine (KB) | 12 | 14 | 375 |
| Usambarensine (KB) | 9.7 | 6 | 16 |
| 10′-Hydroxyusambarensine (HeLa) | 20 | 19 | 56 |
| Strychnopentamine (KB) | 11.3 | 96 | 78 |
| Tetradehydrolongicaudatine Y (HeLa) | >50b | >40 | >52 |
a
Selectivity index is defined as the ratio of cytotoxicity (IC50) to antiplasmodial activity (IC50).
b
This compound has no effect at 50 μM.