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. 2022 Mar 24;17(3):e0265770. doi: 10.1371/journal.pone.0265770

Table 3. Triggers for FBT and physiological expectations.

Reasons for bolus Main reason, N (%) Secondary reason, N (%) Expectation, median (IQR)
After bolus One hour after bolus
Hypotension (mmHg) 36/77 (47%) 12/77 (16%) 2.6 (-3.1–6.8) 1.3 (-3.5–4.1)
Poor urine output (ml) 16/77 (21%) 13/77 (17%) N/A 0.0 (-47.5–20.0)
Tachycardia (bpm) 14/77 (18%) 13/77 (17%) -4.2 (-11.0–0.0) -3.7 (-9.6–0.2)
Low cardiac index (L/min/m2) 5/77 (6%) 5/77 (6%) 0.06 (-0.05–0.31) 0.00 (-0.12–0.20)
High lactate (mmol/L) 4/77 (5%) 6/77 (8%) 0.0 (-0.2–0.3) -0.2 (-0.4–0.2)
Low CVP (mmHg) 2/77 (3%) 3/77 (4%) 0.5 (-0.7–2.4) 0.0 (-1.1–1.6)
Low SvO2/ ScvO2 (%) 0/77 (0%) 1/77 (1%) Too small sample size Too small sample size
None given N/A 24/77 (31%) N/A N/A

Values are presented as median with (IQR) or numbers (percentages) of patients.

MAP = Mean arterial pressure. UO = Urine output. HR = Heart rate. CI = Cardiac index. CVP = Central venous pressure. ScvO2 = Central venous oxygen saturation. N/A = Not applicable.