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. 2022 Mar 18;11(6):1030. doi: 10.3390/cells11061030

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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ROC curve comparison for the reference and selected diagnostic models. (A) ROC curves and AUCs for the reference models (sex + age + MMSE score) with (green) or without considering cerebral AD (blue) and the final diagnostic models of the occurrence of NPS obtained after addition of three proteins (IDS + RELN + SH3L3) without AD (red) and three proteins (MIME + IDS + K22E) with AD (magenta). (B) ROC curves and AUCs for the reference model (age + sex+ baseline MMSE score + time to follow-up + cerebral AD status (blue)) and the final diagnostic model of decline in global cognition (MMSE change at last follow-up <−2) after addition of three proteins (IDS + PGS1 + AP2B1).