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. 2022 Mar 17;11(6):1024. doi: 10.3390/cells11061024

Figure 2.

Figure 2

Representative sections from hippocampus (A–D) and brainstem (F–K) of wild type mice (A,B,F–H) and female hTau mice (C,D,I–K) infused with IgG from a patient with anti-IgLON5 disease (A,C,F,G,I,J) or from a control subject (B,D,H,K). The asterisk in (E) indicates the area of analysis of the phosphorylated Tau protein deposition in the hippocampus at the reported bregma coordinate. (F,I) are magnifications of the areas indicated by the squares in (G,J), respectively. The pathology appeared more severe in hTau than in wild-type mice. Scale bars: (D,I) = 20 μm; (K) = 500 μm. PoDG: polymorph layer of the dentate gyrus; GrDG: granule cell layer of the dentate gyrus; LDTg: laterodorsal tegmental nucleus; DPGi: dorsal paragigantocellular nucleus.