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. 2022 Mar 17;11(6):1024. doi: 10.3390/cells11061024

Figure 7.

Figure 7

Panel (A) shows representative raw tracings of licking behavior in a female hTau mouse upon termination of the 14-day period of intracerebroventricular infusion with antibodies from a patient with anti-IgLON5 disease. ΔV (B–F): electric potential difference between the steel nozzle of the water bottle and an aluminum plate on the cage floor beneath the mouse. Upward deflections of ΔV (B–F) correspond to individual licks. The inter-lick intervals (ILI) are measured as the time intervals between the peaks of ΔV (B–F) deflections (red squares). (B,C): values of ILI at the end of the 14-day infusion (d14) and ≥ 1 month afterward (d45) in female wild-type (blue) and hTau (red) mice infused with antibodies from patients with anti-IgLON5 disease (IgLON5) or from control (CTRL) subjects. Bars show means ± SEM. Dots show values in individual mice. * p < 0.05, ANOVA main effect of IgLON5 vs. CTRL antibodies. Detailed statistical results are reported in Table A11.