Table A4.

Statistical analysis of sleep phenotype: time spent in REM sleep.

	♀ hTau and WT d14 and d45 Total N = 15	♀ hTau and WT d14 Total N = 20	♂ hTau d14 and d45 Total N = 7
ANOVA factor or interaction	p value	p value	p value
Ab (Pt-IgG vs. Ctrl-IgG)	0.690	0.861	0.995
Mouse Strain (hTau vs. WT)	0.614	0.683	N/A
Ab x Strain	0.412	0.683	N/A
Time (d14 vs. d45)	0.536	N/A	0.065
Ab x Time	0.851	N/A	0.446
Strain x Time	0.854	N/A	N/A
Ab x Strain x Time	0.743	N/A	N/A

ANOVA: analysis of variance, with “x” indicating interactions. Ab: antibody. N/A: not applicable. ♀ and ♂: female and male, respectively. The meaning of the other abbreviations is the same as in the main manuscript. Experiments were performed on 4 ♀ WT with Pt-IgG at d14 and d45; 4 ♀ WT with Ctrl-IgG at d14, of which 3 also at d45; 7 ♀ hTau with Pt-IgG at d14, of which 4 also at d45; 5 ♀ hTau with Ctrl-IgG at d14, of which 4 also at d45; 4 ♂ hTau with Pt-IgG at d14 and d45; 3 ♂ hTau with Ctrl-IgG at d14 and d45.