Table A7.

Statistical analysis of EEG power theta/delta ratio during sleep.

	♀ hTau and WT d14 and d45 Total N = 15	♀ hTau and WT d14 Total N = 20	♂ hTau d14 and d45 Total N = 7
ANOVA factor or interaction	p value	p value	p value
Ab (Pt-IgG vs. Ctrl-IgG)	0.293	0.194	0.934
Mouse Strain (hTau vs. WT)	0.046 *	0.004 *	N/A
Ab x Strain	0.132	0.098	N/A
SS (NREM sleep vs. REM sleep)	<0.001 *	<0.001 *	0.001 *
Ab x SS	0.330	0.331	0.947
Strain x SS	0.137	0.015 *	N/A
Ab x Strain x SS	0.142	0.062	N/A
Time (d14 vs. d45)	0.036 *	N/A	0.018 *
Ab x Time	0.595	N/A	0.753
Strain x Time	0.104	N/A	N/A
Ab x Strain x Time	0.506	N/A	N/A
Time x SS	0.117	N/A	0.063
Ab x Time x SS	0.535	N/A	0.460
Time x SS x Strain	0.249	N/A	N/A
Ab x Time x SS x Strain	0.642	N/A	N/A

ANOVA: analysis of variance, with “x” indicating interactions. Ab: antibody. SS: sleep state. N/A: not applicable. ♀ and ♂: female and male, respectively. The meaning of the other abbreviations is the same as in the main manuscript. *: statistically significant (P < 0.05). Experiments were performed on 4 ♀ WT with Pt-IgG at d14 and d45; 4 ♀ WT with Ctrl-IgG at d14, of which 3 also at d45; 7 ♀ hTau with Pt-IgG at d14, of which 4 also at d45; 5 ♀ hTau with Ctrl-IgG at d14, of which 4 also at d45; 4 ♂ hTau with Pt-IgG at d14 and d45; 3 ♂ hTau with Ctrl-IgG at d14 and d45.