Table A8.

Statistical analysis of sleep apnea occurrence rate.

	♀ hTau and WT d14 and d45 Total N = 13	♀ hTau and WT d14 Total N = 19	♂ hTau d14 and d45 Total N = 7
ANOVA factor or interaction	p value	p value	p value
Ab (Pt-IgG vs. Ctrl-IgG)	0.665	0.337	0.307
Mouse Strain (hTau vs. WT)	0.169	0.019 *	N/A
Ab x Strain	0.345	0.412	N/A
SS (NREM sleep vs. REM sleep)	0.431	0.065	0.002 *
Ab x SS	0.384	0.542	0.354
Strain x SS	0.551	0.678	N/A
Ab x Strain x SS	0.798	0.382	N/A
Time (d14 vs. d45)	0.693	N/A	0.946
Ab x Time	0.633	N/A	0.844
Strain x Time	0.032 *	N/A	N/A
Ab x Strain x Time	0.342	N/A	N/A
Time x SS	0.095	N/A	0.002 *
Ab x Time x SS	0.146	N/A	0.506
Time x SS x Strain	0.289	N/A	N/A
Ab x Time x SS x Strain	0.189	N/A	N/A

ANOVA: analysis of variance, with “x” indicating interactions. Ab: antibody. SS: sleep state. N/A: not applicable. ♀ and ♂: female and male, respectively. The meaning of the other abbreviations is the same as in the main manuscript. *: statistically significant (P < 0.05). Experiments were performed on 4 ♀ WT with Pt-IgG at d14 and d45; 4 ♀ WT with Ctrl-IgG at d14, of which 3 also at d45; 7 ♀ hTau with Pt-IgG at d14, of which 3 also at d45; 4 ♀ hTau with Ctrl-IgG at d14, of which 3 also at d45; 4 ♂ hTau with Pt-IgG at d14 and d45; 3 ♂ hTau with Ctrl-IgG at d14 and d45.